PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4096)
Related Products (4096)
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PROTAC Linkers Isoform Comparison
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PC DBCO-PEG4-NHS ester
0 ImagesCat. No.: HY-138756CAS No.: 2055025-02-8
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DBCO-NHCO-PEG3-Fmoc
0 ImagesCat. No.: HY-133472CAS No.: 2752326-54-6
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N-Boc-PEG6-alcohol
0 ImagesCat. No.: HY-W071584CAS No.: 331242-61-6N-Boc-PEG6-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG6-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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PEG5-Tos
0 ImagesCat. No.: HY-23417CAS No.: 155130-15-7
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SMPH Crosslinker
0 ImagesCat. No.: HY-124318CAS No.: 367927-39-7
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Azido-PEG23-amine
0 ImagesAzido-PEG23-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG23-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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HS-PEG3500-NH2 hydrochloride
0 ImagesCat. No.: HY-168937DPurity: 99.81%HS-PEG-NH2 (Mn 3500) hydrochloride is a bifunctional cross-linker that can be used to synthesize PEG hydrogels.
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Hydroxy-PEG4-acid
0 ImagesHydroxy-PEG4-acid is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Bis-aminooxy-PEG1
0 ImagesCat. No.: HY-140407CAS No.: 93460-33-4
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N-Mal-N-bis(PEG4-NH-Boc)
0 ImagesCat. No.: HY-140575CAS No.: 2128735-27-1
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Hydroxy-PEG9-Boc
0 ImagesCat. No.: HY-141205CAS No.: 2055042-66-3
